Hereditary breast and ovarian cancer molecular mechanism and clinical practice

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Bibliographic Details
Other Authors: Nakamura, Seigo (Editor), Aoki, Daisuke (Editor), Miki, Yoshio (Editor)
Language:English
Subjects:
Online Access:Link to e-book
Physical Description:1 online resource
Published: Singapore : Springer, 2021.
ISBN:9789811645211
9811645213
Table of Contents:
  • 1 History, Advancements, and Future Strategies
  • 2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis
  • 3 Genetic Testing
  • 4 Variants of uncertain significances in hereditary breast and ovarian cancer
  • 5 Genetic counseling in Hereditary Breast and Ovarian Cancer
  • 6 Hereditary Breast Cancer
  • 7 Hereditary Ovarian Cancer
  • 8 Risk-Based Breast Cancer Screening
  • 9 Chemoprevention for Breast Cancer
  • 10 Chemoprevention for Ovarian Cancer
  • 11 Risk-Reducing Mastectomy (RRM)
  • 12 Risk-reducing salpingo-oophorectomy (RRSO)
  • 13 Panel Testing
  • 14 Germline Findings through Precision Oncology for Ovarian Cancer
  • 15 Germline Findings from Genetic Testing for Breast Cancer
  • 16 Hereditary Breast and Ovarian Cancer (HBOC) Database
  • 17 Ethical Issues: Overview in Genomic analysis and Clinical Context
  • 18 PARP Inhibitors-Mechanism of action
  • 19 PARPi - Efficacy in Hereditary Breast Cancer
  • 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer.